411 papers
This study utilizes a somatic mouse model of Trp53R245W mutation to identify three distinct intrinsic metastatic breast cancer subtypes (stem-cell like, well-differentiated metabolically active, and immunosuppressed) characterized by unique transcriptomic profiles and genomic alterations, thereby elucidating potential therapeutic targets for this deadly disease.
This study proposes a hybrid framework combining Differential Evolution and Physics-Informed Neural Networks to accurately estimate parameters in tumor-immune ODE models for bladder cancer, enabling robust, data-driven personalization of treatment strategies despite sparse and noisy clinical data.
This study reveals that the tumor suppressor BAP1 safeguards genomic stability in uveal melanoma by preventing aberrant H2AK119 ubiquitylation-driven DNA end resection, thereby ensuring proper recruitment of repair factors for both homologous recombination and non-homologous end-joining pathways.
This study elucidates that Api5 overexpression drives breast epithelial cell transformation by upregulating FGF2, which subsequently activates the PDK1/Akt and Ras/MAPK/ERK signaling pathways to regulate proliferation, morphology, polarity, and apoptosis.
This study demonstrates that microRNA-28 (miR-28) effectively inhibits the development of ibrutinib resistance in ABC-DLBCL by disrupting clonal selection and downregulating mitochondrial and mTOR signaling pathways, thereby suppressing tumor growth in vivo and correlating with improved patient survival.
This study identifies the loss of piR-hsa-7221 regulation as a key driver of CASC9 oncogenic lncRNA expression in testicular germ cell tumors, revealing a novel epigenetic mechanism that promotes tumor progression and cisplatin resistance while highlighting potential new therapeutic targets.
This study reveals that lung cancer-enriched p53 mutants (specifically V157F and R158L) uniquely retain the ability to bind canonical target genes but fail to activate transcription, representing a distinct loss-of-function mechanism that occurs post-DNA binding and exerts a dominant-negative effect on wild-type p53.
Menin inhibitors sensitize KMT2A-rearranged and NPM1-mutated acute myeloid leukemia to CLEC12A-directed CAR T cell therapy by inducing robust CLEC12A expression without impairing immune cell function, resulting in superior disease control and prolonged survival in preclinical models.
Contrary to the tumor-suppressive effects observed in vitro and in immunodeficient models, a plant polyphenol mixture unexpectedly accelerated liver metastasis in immunocompetent mice by inducing peritumoral inflammation, a process that was reversed by anti-inflammatory treatment.
This study demonstrates that targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer by reversing MHC-I downregulation and M2 macrophage enrichment, thereby synergizing with PI3K inhibition and anti-PD-1 therapy to enhance durable antitumor immunity.
This study demonstrates that SARS-CoV-2-specific T cells can cross-react with tumor-associated antigens through molecular mimicry, as evidenced by the identification of unique, individual TCR clonotypes that recognize both viral and tumor peptides, suggesting a promising strategy for developing off-the-shelf cancer vaccines.